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Subclinical Hypothyroid Patient feels 100% Better after 30 Days

“Dr Clark, Hi! Since I started this protocol you sent me I have felt 100% better in every way –although the Candida is still there but it is better. “

–Angie, 37 year old music teacher

Angie came to me diagnosed with Subclinical Hypothyroidism (high TSH, but everything else normal)…

…and suffering with symptoms of:

  • weight gain
  • lack of energy
  • depression
  • cold hands & feet
  • food intolerances
  • gas and bloating.

I did a complete blood chemistry work-up on her to find out– mainly–if she had Hashimoto’s….she didn’t. Both her TPO and TGB antibodies were negative.

BUT Angie did have these important findings on her blood tests:

  • High cardio-C reactive protein (inflammation)
  • Poor magnesium (1.7) –so poor carbohydrate metabolism
  • Iron deficiency (ferritin level 25) – almost guaranteed to cause fatigue and low energy, not to mention depression
  • Low Vitamin D (27)–so, a lot of inflammation since Vitamin D regulates your immune system
  • Poor folate levels (9.8) — HIGHLY linked to depression and low energy
  • Poor B12 levels (320) – HIGHLY linked to depression and low energy

She started her drug-free treatment plan 30 days ago, and sent me that wonderful update…she’s feeling 100% better!

Look, not EVERY woman with low thyroid has Hashimoto’s. The key to successful treatment of low thyroid symptoms is doing the right tests to dig deep and find the REAL cause of your symptoms. So make sure you’re working with someone who will be a good detective and do that hard work for you.

…Oh, and 30 days of any treatment plan is plenty of time to find out if you’re on the right track or not.

Hidden Cause #21 Why You STILL Have Low Thyroid Symptoms-High Cortisol Blocking Receptors

Dr. David Clark, DC – Raleigh-Durham-Chapel Hill thyroid expert, explains how high Cortisol causes Low Thyroid symptoms.

Hidden Cause #21 why you STILL have low thyroid symptoms even though you may be taking thyroid medication, and even though your lab tests may look normal is…

High cortisol suppressing thyroid hormone receptors.

Now, we’ve talked before about cortisol doing a couple other negative things in terms of thyroid hormone chemistry (affecting conversion and the pituitary).

But this one today is one in which cortisol levels are too high and suppress the receptors for T3. 

What symptoms would high cortisol dampening these receptors cause?

It would cause low thyroid symptoms like these:

  • brain fog
  • depression
  • hair loss
  • weight gain
  • constipation
  • dry skin, dry hair
  • muscle pain
  • infertility
  • high cholesterol. 

If you have those symptoms and go to your doctor–and they order a TSH and T4–you might get diagnosed as hypothyroid and start taking medication like Synthroid® or Armour®….

But, if you have this cortisol problem, you won’t feel any better.

This happens all the time…

So, you could have all the medication you want floating around in your bloodstream.  But even if the hormone docks onto the receptors, nothing happens. Nothing “clicks.”

Another way of talking about this is to call this “resistance.”

See, there’s a receptor on the inside of the cell.  And when the hormone comes along and docks, it causes some changes inside the cell because messages go to the nucleus of the cell and DNA starts to produce different proteins.

High cortisol basically shuts down the message from traveling from the receptor into the nucleus of the cell.  

So, if you’ve got the type of scenario in which you were diagnosed hypothyroid but you’re taking medication AND the labs look normal BUT you still feel low thyroid– well, then this could be one of the reasons why.  

There’s another scenario in which you never got diagnosed hypothyroid in the first place  because your lab numbers look totally normal the whole time. 

This actually happens quite a bit. 

You still have those low thyroid symptoms we just talked about.  But your T4, TSH, T3, all that looks normal. 

Blood tests don’t look at receptors.  Blood tests can look at levels of T4, T3 etc.  They can look at levels of thyroxine-binding globulins.  They can look at Reverse T3.  But there’s no way for blood tests to look at what’s going on at the level of the receptors. 

So, finding this hidden cause is a process of elimination. 

What causes high cortisol? 

…The three big reasons are:

  1. Inflammation
  2. Stress
  3. Diet

#1 – So, let’s start with inflammation…

Anything that inflames you can cause high cortisol throughout your body. Things like these:

  • Food sensitivities (you probably don’t know you have)
  • Leaky Gut
  • Infections (parasites, viruses, bacteria)
  • Dybiosis (bacterial/fungal/yeast imbalances & overgrowths in the small or large intestine)

…they can all cause you to have HIGH cortisol and suppressed thyroid hormone receptors and low thyroid symptoms. 

#2 – Psychological and emotional stress are a big source of high cortisol. 

Who doesn’t have stress?  The problem is if you have too much stress over the long term…or a super large single stressful event, like a divorce or a trauma…that causes you to secrete a lot of cortisol. 

That cortisol can flood the body…suppress the activity of the thyroid receptor…and you suffer low thyroid symptoms.  

#3- A bad diet can also create HIGH cortisol.  

Eating lots of refined sugars, stimulants (caffeine & artificial sweeteners) and simple carbs will cause high cotisol that will shut down those thyroid hormone receptors. 

High cortisol messing with your thyroid hormone receptors is a hidden cause–and it’s quite a ways down on our list because to find it, your doctor has to eliminate all other possibilities.  

To do THAT,  your doctor has got to be able to give your history a thorough review–not just spend 5 minutes without even looking you in the eye. Your doctor would need to be able to RECOGNIZE what you’ve already tried that didn’t work. 

Or realize that even though your lab tests are “normal”, you could legitimately still have  low thyroid symptoms. Your doctor needs to spend some time really thinking hard about your case.

Sadly, that’s two things  a lot of doctors don’t want to do: spend time and think. 

Based on the stories my patients tell me, there’s a LOT of doctors out there who would really like for you to just show up, pay, leave and the doc never have to talk to you. 

I’ve met doctors like that. 

And I’m beginning to think there’s more and more of them.  I think they all still want to help.  They just don’t want to exert a lot of effort. 

So, to get help you must find someone that understands this fact: there’s a lot of reasons why you can have low thyroid symptoms.  And then tries to work through the possibilities.

How? By AT LEAST asking for a  complete history to discover what you’ve already tried (meds, supplements etc) that has or has not worked.  

Next, obtaining the necessary lab tests to investigate the possibilities I’ve listed above. 

Your doctor has got some work to do. 

© 2014 David Clark. All Rights Reserved.

Disclaimer: The contents of this site are for educational purposes only. Nothing here should be construed as medical advice. Nothing here is a substitute for actual medical care. Consult a qualified healthcare professional.

Hidden Cause #17 Why You Still Have Low Thyroid Symptoms – Peripheral Dopamine Deficiency

Dr. David Clark, DC - Raleigh-Durham-Chapel Hill Thyroid expert, explains how low dopamine can cause low thyroid symptoms

Hidden Cause #17 Why You STILL Have Low Thyroid Symptoms even though you may be taking thyroid medication, even though your lab tests look normal is...

A peripheral deficiency in the neurotransmitter Dopamine

What would that look like? Well, there’s really not a lot of peripheral signs of dopamine deficiency.

Most of dopamine deficiency signs happen because of it's effect on your central nervous system and how your brain is working....and those are typically things that look like ADHD: so we’re talking about

  • distractibility
  • impulsivity
  • can’t focus
  • can’t stay on task

But there’s also some sort of, you know, emotional symptoms that go along with that.

Let's clarify "deficiency." In most people, absolute low quantities of dopamine are not the problem. In most people the problem is low activity of the neurotransmitter.

Deficiency implicates that you’ve got absolute low levels, but it could be that your levels are fine...and it’s just that the receptors for the dopamine are not doing their job.

So with that in mind, what are some of the emotional signs that go along with dopamine being low activity or deficient?

  • Preferring to isolate oneself
  • Anger under stress

My favorite example of this last one is my own personal example. It was about 16 years ago....

I was in the kitchen cutting up an apple, and the apple fell in the sink and I yelled a 30 second stream of expletives.

My wife ran into the kitchen, struck with terror...“Oh my God, what happened? Are you hurt?”

I screamed back:  "This APPLE FELL in the sink!"

Well, you understand that’s completely out of proportion, right? I had a little bit of stress and I got very angry. That's a good sign of a dopamine issue.

How would dopamine and thyroid symptoms show up in someone that has that problem?

Well, first thing they could have are low thyroid symptoms:

  • hair loss
  • brain fog
  • fatigue
  • high cholesterol
  • gain weight easily
  • infertility
  • constipation.

Those are those low thyroid symptoms.

Now, if you had those PLUS dopamine sypmptoms, the two could be directly related because what dopamine seems to do to thyroid hormones.

Research seems to say that Dopamine controls the rate of conversion of T4 into T3.

That's a very big deal because T4 is inactive. T3 is the active thyroid hormone. 97% of what your thyroid gland makes is T4-- and so a lot of that has got to get converted to T3 in order for you to have enough T3 for your body to work correctly.

That process is  conversion. And dopamine seems to influence how well you can convert T4 into T3. When you don’t have enough dopamine peripherally (outside the central nervous system) you may not convert very well...

You may develop those low thyroid symptoms. The problem is when you walk into a doctor’s office in saying, “Hey, I can’t focus. I’m distractible. I can’t follow through on things.” Bonk! You're going to get labeled ADHD and offered a prescription.

But the dopamine medication is going to work mainly CENTRALLY and not work peripherally. You might have an improvement of some of your distractibility and your focus problems, but your low thyroid symptoms may stay exactly the same.

The key is finding a doctor that understands that dopamine has an impact on how thyroid works.

You could be taking thyroid medication. You could have lab tests that look totally normal because when this situation happens your T4 and your T3 don’t really necessarily change a lot to be outside of the lab range, but they can change enough to affect how you feel.

And it becomes very difficult for most doctors to do because they want to treat the labs.

I think a really good doctor/good clinician  doesn’t treat the lab. They treat YOU.

They use the lab for guidance.

So if you have dopamine symptoms plus low thyroid symptoms, then your doctor really should have that on the radar and think: what could cause dopamine deficiencies?

The two things that cause low dopamine activity/deficiency: blood sugar irregularity and iron deficiencies.

And that makes you go down another rabbit hole because...

..."why would you be iron deficient?"

...Do you have a parasite?

Do you have an H. pylori infection?

What’s up with your blood sugar? Are you eating? Are you not eating?

There’s a ton of factors to start investigating and thinking about....

And that’s another thing that a lot of doctors just don’t want to do. They just don’t want to think. They’d much rather you come in with your ADHD signs, give you medication for that and hope everything works out.

And when you come back six months later and it’s not working out... it’s YOUR fault, the patient.

Find someone that understands the complexity of that situation and understands that dopamine can be a hidden cause of why you still have low thyroid symptoms.

© 2014 David Clark. All Rights Reserved.

Disclaimer: The contents of this site are for educational purposes only. Nothing here should be construed as medical advice. Nothing here is a substitute for actual medical care. Consult a qualified healthcare professional.

Relief for PhD Candidate with Hashimoto’s Brain Fog and Fatigue

Natalia suffered with Hashimoto’s hypothyroid brain fog and fatigue even though she was taking thyroid hormone medication. Her symptoms were so bad she couldn’t write her doctoral dissertation, couldn’t deal with her children.—And, in her words “I felt so Inert.”

After only 30 days of treatment, her foggy brain disappeared, and then her energy improved and she felt like her old, active self. After 120 days, she says she’s 80% improved.

Natalia summed up her experience so far with this statement:
“Don’t believe the doctor who tells you that there’s nothing you can do for Hashimoto’s, because that’s NOT true.”

Many women with Hashimoto’s, like Natalia, STILL suffer these low thyroid symptoms even though they take medications like Synthroid®, Armour® and Cytomel®…and even though their lab results are “normal.”

  • Hair loss
  • constipation
  • weight gain
  • infertility
  • sleep problems
  • depression



Hidden Cause #10 Why You STILL Have Low Thyroid Symptoms – Antibodies to Your Own T4 & T3

Hidden Cause #10 why you STILL have low thyroid symptoms even you’re labs are “normal,” and even though you’re taking medication is:

An Autoimmune attack on your own T4 and T3 thyroid hormones. 

Now, this situation happens very commonly in people that already have some type of autoimmune condition (like Multiple Sclerosis, Celiac Disease, Rheumatoid Arthritis) and specifically it happens frequently in people that have Hashimoto’s.

So let’s give a little background…

Hashimoto’s is by far the most common cause of low thyroid or hypothyroidism—by far.  It’s an autoimmune condition.

Ironically, a lot of people will get tested for Hashimoto’s—and the test will show positive for Hashimoto’s, but…crazily…

Doctors don’t really do anything about the autoimmune problem other than give you replacement hormones like Synthroid®, Armour® or Cytomel®.

And to be fair, the replacement hormones will help some—but typically what happens over time is you end up feeling the exact same way you did before you were taking the thyroid hormones.

You have

  • constipation
  • depression
  • fatigue
  • hair loss
  • brain fog
  • nfertility symptoms
  • joint pain & muscle pain
  • sleep problems

Those symptoms are STILL with you even though you’re taking the medication the way you’re supposed to. How you react when you take the medication can be a clear sign and indication that you’ve got an attack on T4 and T3.

So here’s what I mean…

So let’s say you have those low thyroid symptoms.  You go to your doctor.  You get diagnosed as hypothyroid—but they don’t test for the Hashimoto’s antibodies–and they give you Synthroid®.

You take Synthroid®  but it doesn’t really do anything for your symptoms. So you read some article on the Internet about “bio-identical” thyroid hormones being superior to synthetic.  The internet information says Nature-Throid® or Armour® is the way to get releif.  You think:

“That sounds logical. Bio-identical is better because it’s natural.  I’m going to try it.”

When you take the Bio-identical thyroid hormones…suddenly you have a huge flare-up of symptoms,  a bad reaction to this bio-identical thyroid hormone that’s supposed to be better than synthetic.

What the heck is going on?

The first thing that’s probably happening, especially if you’re suffering swelling or headaches, pain, is you are attacking your own thyroid hormones.

Armour® and Nature-Throid® are bio-identical, meaning they look a lot like your own T4 and T3 hormones. If you’re already attacking the T4 and T3 that you make — and then you start to take some hormones that looks just like it–it’s just like throwing kerosene on a burning fire.  That’s why you get this sudden flare-up and feel worse.

Why would you be attacking your own T4 and T3? 

It’s usually the result of a progression of autoimmunity.  First, you’ve attacked the inside of your own thyroid gland–and you’re attacking thyroid peroxidase and/or thyroglobulin inside the thyroid gland.

Now, once that happens, the normal tolerance to yourself is broken. It’s gone.  Now your immune system can attack any other tissue, gland or hormone.

And it’s easier and quicker for your immune system to attack what’s in close proximity to the thyroid peroxidase and the thyroid globulin– the T4 and T3 hormones you’re making inside your gland.

This happens to a lot of people that develop undiagnosed Hashimoto’s.  No doctor diagnoses them with Hashimoto’s, and they don’t really find out they’ve got Hashimoto’s (or autoimmunity at all) until… they switch from a synthetic medication to a bio-identical.  That’s one scenario.

Here’s a second scenario that I really hope doesn’t happen to you.

A woman has these low thyroid symptoms.  She’ll get diagnosed hypothyroid.  They don’t test for Hashimoto’s, and she’ll be taking Synthroid or Levothyroxine for awhile.

And then she just decides that she wants to try something  else and see if it works better. Keep in mind.she actually feels “olay” on the synthetic thyroid hormones, but  she wants to see what might work better.

She consults that information wonder the Internet and reads something about Armour® and Nature-Throid® being superior. So she switches from synthetic to bio-identical and suffers this huge flare-up, bad reactiion.

The reason I’m bringing that up is if you’ve already got a medication that’s working for you…you’re feeling really good or, at least not bad, on synthetic medication…don’t switch.

Because if you switch, there’s a 50/50 chance you’re going to  have a really bad reaction.

If you do have a bad reaction to this bio-identical, that’s a sure sign that you’ve got autoimmunity and that you’re attacking your own T4 and T3. And, that before the T4 and T3 attack happened, you were attacking your own Thyroid Peroxidase and Thyroglobulin.

This is a hidden cause because most doctors have no idea what’s going on if you have a bad reaction to Armour® ,or a bad reaction to the Nature-Throid®.  I don’t care if they’re a DC, MD,  ND, whatever.  It confuses them.  They don’t understand why that’s happening.  If you’re having a reaction to that, it’s probably because you just threw some gasoline on the fire.

It’s the same thing as if you were to take iodine if you had Hashimoto’s.  Why is that?  Because iodine stimulates the production of TPO, which is what you’re attacking in Hashimoto’s. So you’re just giving your immune system more things to attack.

I think Quest now offers a T4 and T3 antibody test, but I’ve got to tell you there’s really no point in running that because the ranges are so ridiculously wide that I’ve seen that you’re probably not gonna show up positive for it anyway.

if you have a bad reaction to Armour® or a bad reaction to Nature-Throid® or another bio-identical, you probably have an autoimmune attack on your own T4 and T3 thyroid hormones…and you probably have Hashimoto’s as well.

You need to find a doctor that understands what to do with that Hashimoto’s and autoimmune problem because you are probably going to nned to switch back to synthetic. However — switching is not going to address the autoimmune problem.  That autoimmune fire is still burning, so you’ve got to find somebody that can help you deal with it.

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© 2013 David Clark. All Rights Reserved.

Disclaimer: The contents of this site are for educational purposes only. Nothing here should be construed as medical advice. Nothing here is a substitute for actual medical care. Consult a qualified healthcare professional.

Hidden Cause #9 Why You STILL Have Low Thyroid Symptoms – TSH Receptor Antibodies

Hidden Cause #9 Why you still have low thyroid symptoms is you have anti-TSH receptor antibodies.

That was a mouthful.  Let me say it again.

Hidden Cause #9 why you still have low thyroid symptoms even though your labs are “normal” and even though you take medication…is you have antibodies against the receptors for thyroid-stimulating hormone.

Now, this is semi-technical but I’m going to explain it to you this way:

Normally the pituitary gland sends a signal to your thyroid gland called TSH (Thyroid Stimulating Hormone). The TSH then tells the thyroid gland to make T4 and T3.

Hidden Cause #9 is an autoimmune situation that affects TSH.  The more common autoimmune cause of low thyroid symptoms is, of course, Hashimoto’s, which we’ve talked about.  But you can make antibodies to the little receptors for TSH.

This antibody is often called a thyroid-simulating immunoglobulin.  Typically, people that have antibodies against this TSH receptor are thought of as having Graves’ disease.

Graves’ disease is a hyperthyroid condition. It’s completely different than low thyroid.  So why am I saying this is a hidden cause for low thyroid symptoms?  Because there’s no rule about what these antibodies are going to do to that TSH receptor.

In Graves’ disease, they attach onto the receptor and they stimulate more  TSH and more thyroid hormones causing hyperthyroidism.  But there’s no rule that they’re going to do that every time.

TSH receptor antibodies also show up in people that have Hashimoto’s. 

TSH receptor antibodies can bind to TSH receptor and block it…Meaning it’s like you’re not getting any TSH.  And if you’re not getting any TSH, you’re not going to make any T4 and T3 and you’re going to become hypothyroid.

What kind of symptoms would you have?  You would have the classical hypothyroid symptoms:

  • constipation
  • depression
  • hair loss
  • fatigue
  • brain fog
  • high cholesterol
  • infertility
  • joint pain

Those are all things that you could have if you had TSH receptor antibodies.

Very few doctors check for these antibodies in someone that has LOW thyroid symptoms.  If you ask endocrinologists, GPs, naturopaths, acupuncturists, or even a doctor who understand functional medicine….

…and you ask them “What kind of symptoms would make you want to run TSH receptor antibodies?”  They would not say low thyroid.  What they would say are symptoms like increased heart rate, racing heart, racing pulse, racing thoughts, feeling shaky.  Those are all Graves’ disease symptoms.

Now here’s where it gets really confusing…

A person with Hashimoto’s can swing back and forth between low thyroid symptoms and periodic, temporary hyperthyroid symptoms.

The reason that swing is happening in Hashimoto’s  is because you get a flair up and the immune system attack that’s going on inside your thyroid gland, and it explodes a little segment of your thyroid gland…and dumps active free-state hormones into your blood.

Then you get hyperthyroid symptoms.

TSH receptor antibodies are typically thought of as something that you only check for in Graves’ disease.  And this is why it’s a hidden cause.

Follow what I’m saying….

You could have negative TPO antibodies.  You could have negative TGB antibodies.  But you could have positive TSH receptor antibodies and still be a Hashimoto’s case— And still be low thyroid.

I would be very surprised if you found a doctor in any field who would run that test and interpret it that way.  But that’s just the fact.  That’s what the literature shows.

How common are TSH receptor antibodies in Hashimoto’s?  Not very common but that’s also why it could be hidden.

If you look like you have Hashimoto’s.

If you act like you’ve got Hashimoto’s.

If people think you’ve got Hashimoto’s but they won’t do anything for you because they can’t prove you’ve got Hashimoto’s….then you might need this TSI or TSH receptor antibody test.

If the TSI or TSH Receptor antibodies are positive– and you’re hypothyroid, then you may have Hashimoto’s.  That’s when you have to take quick action.

Because now you’ve got an autoimmune condition.  And there a tone of things that can be done for that.  There’s things you need to avoid like the plague.  You must find someone that can help guide you through that like a detective.  Because there’s a lot of mistakes you can make along the way.

Trust me.  I see people in here every day that make mistakes like taking iodine, taking tyrosine.  These are mistakes until you find out what’s going on with you.

Hidden Cause #9 is TSH receptor antibodies, also called thyroid-stimulating immunoglobulins.  These antibodies can bind or block the receptor and cause you to have hypothyroid symptoms.

15% of Hashimoto’s patients test negative for TPO and TGB.  But some of these same people test positive for TSH receptor antibodies.  The moral of the story is get tested.  And then find someone that knows what to do to help you.

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© 2012 David Clark. All Rights Reserved.

Disclaimer: The contents of this site are for educational purposes only. Nothing here should be construed as medical advice. Nothing here is a substitute for actual medical care. Consult a qualified healthcare professional.


Hidden Cause #8 Why You STILL Have Low Thyroid Symptoms

Dr. David Clark, DC -Durham, NC-explains why anti-thyroglobulin antibodies are a hidden cause why you STILL have low thyroid symptoms.

Hidden Cause #8 why you still have low thyroid systems is kind of a cheat.  You’ve probably heard me talk about Hashimoto’s thyroiditis before.  And this hidden cause is related to that. 

Hidden Cause #8 is antithyroglobulin antibodies—you’ve got Hashimoto’s and it’s attacking your thyroglobulin inside your thyroid gland. 

Why are anti-thyroglobulin antibodies a hidden cause of low thyroid symptoms? 

Well, it really shouldn’t be “hidden” because Hashimoto’s is the most common cause of hypothyroidism, bar none.  It’s not iodine deficiency.  It’s not tyrosine deficiency.  It’s an autoimmune condition.  Genes have been turned on that are causing your immune system to target and attack the inside of your thyroid gland. 

What is Thyroglobulin? 

Thyroglobulin is inside your thyroid gland. You use to make thyroid hormones–T4 and T3.  If your immune system is attacking and destroying thyroglobulin, then your ability to make thyroid hormones over time decreases. 

Evenutally you suffer low thyroid symptoms such as:

  • fatigue
  • depression
  • inability to lose weight
  • gaining weight on low calorie diet, or even though  you exercise like crazy
  • dry hair, dry skin
  • infertility
  • high cholesterol.

Because you just can’t make thyroid hormones very well without enough thyroglobulin, you’ll start to develop those low thyroid symptoms at some point. 

On lab testing, your  TSH (thyroid stimulating hormone) levels may go up…. and your doctor may identify the elevated TSH ….and may diagnose you as hypothyroid.  He/she will probably start you on Synthroid® or Armour® or something similar. 

Here’s a problem, though….

If you’ve got Hashimoto’s—and you’ve got the thyroglobulin antibodies—but the doctor doesn’t test for them….then you’re probably not going to feel very different, even if you’re taking the medication.

The replacement hormones don’t do much for the autoimmune attack on thyroglobulin.

This is a hidden cause because most doctors just don’t look for it. 

Why don’t doctors test for anti-thyroglobulin antibodies? 

Because, frankly, they wouldn’t treat you any differently if they found out you had it.  This is the difference between the traditional medical approach and a more functional approach. 

The standard, in-the-box medical approach says it doesn’t matter that you have an autoimmune condition…. It’s good enough to give you thyroid hormones and hope you feel better.

That doesn’t mean your doctor’s trying to make you feel bad. It’s just the limitation of their training. They don’t know that there ARE other things you can do for it.

What should you be doing about Anti-thyroglobulin antibodies? 

If you’ve been diagnosed hypothyroid – I don’t care how long you’ve been diagnosed – and you’ve never had a thyroglobulin antibody test or a TPO antibody test, you need to get those done.

If you’ve got Hashimoto’s you’ve got to jump into action right now. Here’s why….

You must understand that once you’ve got one autoimmune condition (like Hashimoto’s) it’s really easy to get
another autoimmune condition. It’s easy to start attacking more tissues, causing more problems, causing more symptoms.

The other important thing you have to understand about thyroglobulin antibodies is the connection to Mercury toxicity.

A great study recently showed that having only high Anti- Thyroglobulin antibodies–not TPO
antibodies– is associated with high mercury levels.

Hidden Cause #8 is hidden because most doctors don’t look for it.

It’s not hidden to you anymore because now you know it’s something that could be causing all these low thyroid symptoms that you still have…

…Even though you may be taking medication.

…Even though your other lab tests look normal.

Most doctors typically don’t run a full thyroid panel, which includes Anti-thyroglobulin antibodies, because in
their mind they don’t need to because they really only have one tool to offer you: replacement hormones like
Synthroid® or Armour®.

But if you have Hashimoto’s, the replacement hormones aren’t very helpful in the long run.

Sure, you can enjoy a “hormone honeymoon” where you feel good for a few weeks or few months. Over
time, your dosage keeps changing but you still feel bad.

I just wish that doctors would check for these things. I wish more doctors knew that there was something you can do for Hashimoto’s on top of giving thyroid hormones:

  • Changing diet  
  • Make sure the GI tract is healthy–not leaky
  • Decreasing inflammation and cytokine levels
  • Improving Brain function

You have to be an advocate for yourself.

You have some powerful information now, so go find someone to get you tested.

And find someone who’ll know what to do if you show up abnormal. Okay?

That’s the second half of the battle; finding someone that knows what to do with Hashimoto’s.

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© 2012 David Clark. All Rights Reserved.

Disclaimer: The contents of this site are for educational purposes only. Nothing here should be construed as medical advice. Nothing here is a substitute for actual medical care. Consult a qualified healthcare professional.


Just Diagnosed Hypothyroid? You Must Do This Next

If you’ve just been diagnosed with hypothyroidism by your doctor, here’s what you have to do next.

You have to go back to your doctor and demand that he/she run two tests –

  1. TPO antibodies (thyroid peroxidase antibodies)
  2. TGB antibodies (thyroglobulin antibodies)

Why should you yell and scream until your doctor orders these two tests?

Because the most common cause of low thyroid in America is a disease called Hashimoto’s.  It’s an autoimmune condition that can devastate your entire body –not just your thyroid gland.

Elevated TPO antibodies or elevated TGB antibodies indicate that your immune system is targeting and attacking your thyroid gland. Only ONE of the two antibodies needs to be positive to indicate Hashimoto’s.

Low thyroid symptoms are bad enough:

  • hair loss, hair thinning
  • constipation
  • sleep problems – feeling you could sleep 8 hours all over again
  • dry, flaky skin
  • depression
  • brain fog – feeling like your mental responses are slow
  • infertility
  • weight gain -even if you exercise and eat “right”

But, Hashimoto’s can lead to breakdown in the cerebellum, cartilage, nerves, pancreas or stomach.

Most GPs, family practitioners–even endocrinologists–don’t test for Hashimoto’s.  The only reason they ever seem to test for it is to shut up an insistent patient.

Hashimoto’s is an autoimmune condition in which your immune system targets your thyroid gland and literally eats it up – chews it up.  You lose pieces of your thyroid gland and you never get them back.

End results is, you can’t make thyroid hormones and you get low thyroid symptoms like depression, thinning hair, dry skin, constipation, brain fog, infertility, high cholesterol, okay?

If you have just got diagnosed with low thyroid, the next thing your must find out – whether your doctor thinks you should or not – is whether or not you have Hashimoto’s.

Hashimoto’s is a whole other ball game.

Sadly, your medical doctor is probably not going be able to help you with the autoimmune process. They really only have one way to work with any thyroid problem: thyroid  hormone replacement.

POINT: Almost all Hashimoto’s patients are going to require some replacement at some point because they are losing pieces of their thyroid gland.

Problem is —There’s at least 24 different ways that your thyroid hormones can go wrong.  Only one of the 24 responds well to thyroid hormone replacement.  That’s why there’s millions of women who still feel lousy even though their lab tests are normal…Even though they’re taking the thyroid medication like they’re supposed to.

They still feel bad because most of them have Hashimoto’s. And the autoimmune part of the problem has been ignored.

I want you to have hope that you can feel better.  If you’ve been newly diagnosed hypothyroid, you need take action.

You’ve got to stand up for yourself and demand those tests: TPO Antibodies and TGB Antibodies.

What to do when the TPO antibodies and TGB antibodies test results come back….

If TPO & TGB antibodies are negative, two things:

  1. 15% of Hashimoto’s patiens are seronegative–meaning they never test positive for the antibodies but have Hashimoto’s anyway. Keep reading below.
  2. There are 23 other reasons why you could have low thyroid symptoms. Find a doctor to investigate these 23 other causes.

If TPO & TGB antibodies are positive…

You must find a doctor that understands how to approach Hashimoto’s from a functional perspective…someone who understands that there’s even more testing that has to be done.

See, there are triggers for Hashimoto’s…factors that perpetuate Hashimoto’s–keep the fire burning—and we have to investigate and uncover them.

You have to put together the whole jigsaw puzzle and figure out…

  • Why your immune system is out of balance.
  • What’s fueling the fire in your body?

Hashimoto’s low thyroid reality check…

Once you have an autoimmune condition (like Hashimoto’s), chances are good that you will end up with another autoimmune condition.

Here’s what I mean by that…

Normally you’re not supposed to attack and kill yourself, right?  That’s called self-tolerance – when you don’t attack yourself.

I mean, we all make a few antibodies to different tissues.  An antibody is like a little strobe light that your immune system makes to tag what it thinks is an invader…or a dead cell that needs to be cleared out…or a cancer cell.

Then your T cells come by – and they see the strobe light and they attack it and kill it.

Well all of us make a little bit of antibodies to various organs and tissues…but we’re not supposed to make a lot of them.

Because when you make a lot of antibodies, then your T cells – your SWAT team – targets your tissue and kills it.

Depending on what tissue is being attacked, you suffer different symptoms .

In Hashimoto’s self-tolerance is broken.  It’s like a taboo’s been broken.  So now your SWAT team – your immune system – can attack anything it wants.

And it will.  Your immune system can now attack your…

  • cartilage — causing joint pain that looks like arthritis, tendonitis, bursitis
  • ovaries — causing female hormone imbalance, infertility
  • pancreas — causing the blood sugar regulation problems, you might even get diagnosed with Type 1 Diabetes or Type 2 Diabetes
  • lining of your stomach — causing inability to absorb B12 that makes you pernicious anemic.
  • cerebellum in your brain –causing vertigo, dizziness, nausea, car sickness

If you have Hashimoto’s, you need to realize that you have a problem bigger than your thyroid. 

You have an autoimmune condition that needs to be slowed down. This has to be managed correctly or you’ll  end up with problems beyond (and worse) than just low thyroid symptoms. And I know those are awful enough by themselves.

But imagine….

…having depression AND no energy because you’re B12 deficient/ Pernicious Anemic

…having fatigue AND peripheral neuropathy because you have autoimmune diabetes. 

…having hair loss AND car sickness-vertigo-nausea so severe you can’t take a trip to the grocery store

Horrible to think about–even for a second.

This is why the first thing you must do if you’re newly diagnosed hypothyroid  is demand your doctor do those tests –or find somebody else to do them.

If those tests come back negative, there’s about 23 other reasons why you could still have low thyroid symptoms.  And you need to  find a doctor that understands this fact.

If you’ve just been diagnosed with Hypothyroidism,  don’t give up hope.

Don’t get scared into blindly taking thyroid hormones without investigating whether you have Hashimoto’s. Hashimoto’s can and does lead to other autoimmune conditions that can devastate your quality of life.

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© 2011 Dr. David Clark, DC. All Rights Reserved.

Hidden Cause #3 Why You Still Have Low Thyroid Symptoms

Today I reveal  “Hidden Cause Number 3 Why You Still Have Thyroid Symptoms”, even though your labs look normal…and even though you’re taking thyroid hormones.

The third hidden cause of Low Thyroid Symptoms is high levels of cytokines.

Cytokines are messengers that your immune system uses as part of the inflammation process.

Women that have inflammatory conditions such as arthritis, inflammatory bowel conditions, asthma…or autoimmune conditions like Lupus or RA…usally have high levels of cytokines.

High cytokine levels depress and squash the circuit in your brain that helps you make thyroid  hormones.

Cytokines may not squash this circuit so much that your TSH is low according to  “normal reference range.” But remember, the lab ranges that are used to measure TSH and T4, are too WIDE. Too forgiving.

In my office, I use a “functional” range.  It’s a narrow range.  The power of the functional range is that every day I discover  “hidden” thyroid dysfunction using this “functional” narrow range.

“How do you know if I have elevated cytokines?”

Well, these cytokines have names like interleukin 2, interleukin 4, tumor necrosis factor alpha.  You can easily test for these.  These are blood tests.  In fact, these are some of the same  tests that I do for my Multiple Sclerosis, Lupus and RA  patients to find out about exactly how their immune system has become unbalanced.

I do the same deep analysis for the women who have thyroid hormone problems….the women that come in suffering with thyroid symptoms but “mysteriously” their labs are “normal.”

Thousands of women are wandering through life lost, feeling awful, without hope because their thyroid problem is mis-diagnosed and mis-managed.

They feel horrible…they have fatigue, depression, they can’t lose weight. It’s cruel, but they gain weight very rapidly. Ttheir hair is brittle, their nails are brittle, a lot of them are depressed.

But the doctors are telling them, “Well, I just don’t see a reason why you still feel bad.  Maybe I’ll up your prescription–or maybe I just need to give you an anti-depressant.” 

Giving antidepressants to these women is  WRONG.

There are over 24 different ways that your thyroid hormones can go wrong. (24!) And the third way, is when cytokines  get high enough to  put their foot down on that normal circuit that helps you make thyroid hormones.

The next question that must be is… “What’s causing the inflammation?” At the Center for Low Thyroid Solutions I answer this question using a comprehensive analysis.

I use sophisticated lab tests to investigate:

  • Food sensitivities/ intolerance (I use the most sensitive test available)
  • Gastrointestinal infections (totally hidden 80% of the time)
  • Parasites
  • Viral infections
  • Vitamin D deficiency (some women have a genetic problem called a Vitamin D Receptor Polymorphism)

What I’m telling you is that you can’t just accept the fact that your doctor says,

“Your labs are normal; you’re taking thyroid hormones; you still feel bad?; I guess maybe you’re just depressed. Try this antidepressant drug.”

Don’t buy that load of junk!  Do not settle for a life where you feel horrible.

You have to find the right doctor that knows how to assess comprehensively… and knows about these different factors I just told you about (There all in the scientific literature.).

Here’s the giant roadblock in your way….,a scary large number of doctors don’t read.  Even the so-called “number one” endocrinologist in your city– many of them don’t read.

What I do is not their approach.  They do not take a functional approach.  They’re looking just at the lab ranges and if the lab numbers are okay, you’re okay.

Ridiculous isn’t it? These doctors have forgotten how to think.

Today I’ve shared with you how cytokine elevations can cause low thyroid symptoms.  You can test for these with simple but specialized blood tests.

Do NOT settle. You don’t have to suffer.

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© 2010 Dr. David Clark

Hidden Cause #2 Why You Still Have Low Thyroid Symptoms

Today I’m going to reveal hidden cause number two, why you still have thyroid symptoms.

This series is designed to do is to help open your eyes so that you can understand why you still are suffering with symptoms like fatigue and hair loss, low libido, feeling cold….understand why you still have those symptoms even though you’re taking thyroid hormones…. or even though your thyroid numbers look normal.

And hidden cause number two why you’re still suffering is because of a neurotransmitter called Dopamine.

Now I’m going to keep this science really simple…..

Your pituitary, which is a very small gland in your brain, makes thyroid stimulating hormone – TSH.

I’m sure you probably heard of that because that’s probably the only thing your doctor is monitoring, right?

Monitoring TSH is the only thing the status quo medical model does when it comes to thyroid hormone problems.

Pretty much no matter what the doctor thinks your problem might be (and they really only think it’s about one of two things) you get prescribed thyroid hormones.

The doctor doesn’t actually manage your thyroid problem… the doctor manages your TSH.(!)

So, if your TSH gets too high, well they increase your medication.  If your TSH gets too low, they decrease your medication. (so easy I could teach a 5 year old to do it).

The doctor looks at your TSH levels as the Be-All End-All… that couldn’t be more wrong.

The  thing about thyroid hormone problems that confuses most doctors and endocrinologists is there are  about 24 different ways that your thyroid hormones can go wrong – 24.

And most of your doctors are only testing TSH and total T4 and that’s about it.  That’s going to detect only 1, maybe 2 of the 24 different patterns.

The one I’m revealing to you today is Dopamine.

Your hypothalamus in your brain tells the pituitary to make TSH.

The Dopamine problem and its connection with thyroid works like this...there has to be sufficient Dopamine in your hypothalamus to generate the signal to pituitary to make TSH.

If there’s not enough Dopamine activity in your brain, then your pituitary doesn’t know how to make TSH.

Now, The TSH number on your labs will be within the normal lab range, but outside what I call the functional range.

The functional range is different than the lab’s range, because the lab range is pretty much garbage as a reflection of optimal function. It’s so wide that only the very high and very low get flagged.

…So with this Dopamine problem your TSH looks normal but you have thyroid symptoms—cold, fatigued, depressed, can’t lose weight, hair loss.  You may even be taking thyroid hormones.

“How Do I Know if You Have the Dopamine Problem?”

The clue to the Dopamine problem is  that you have, along with the fatigue and libido problems and the depression and the constipation and the can’t lose weight—along with those thyroid symptoms you have Dopamine symptoms.

The classic symptoms of insufficient Dopamine are:

  • feelings of worthlessness
  • anger and aggression when under stress
  • feelings of hopelessness
  • difficulty paying attention
  • distracted from task
  • inability to finish tasks
  • self-destructive thoughts


  1. If you’re suffering with those Dopamine symptoms
  2. AND you’re suffering with those thyroid symptoms
  3. BUT your TSH looks normal
  4. AND you’re taking thyroid hormone…

Then there’s a really good chance that Dopamine is why you still have a thyroid problem.

This Dopamine problem can be helped with special diet modification, lifestyle changes and specific supplementation.

Blood sugar control is probably the biggest thing to look at because Dopamine synthesis is  linked with blood sugar fluctuations.

ALERT: I don’t want you to fall victim to  the idea that you can test central nervous system neurotransmitter levels with urine testing.  That’s not valid at all.

I use an extensive questionnaire that helps me pinpoint specifically if you do actually have those Dopamine problems.

If you do, then I have to start digging into WHY do you have those Dopamine problems–this takes some detective work.  That’s what a good doctor will do.

If you’re suffering with thyroid hormone symptoms AND those Dopamine symptoms, dopamin can be the reason why you are still suffering, even though your labs look normal.

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© 2010 Dr. David Clark